ABSTRACT
Dyslipoproteinaemia is one of the several risk factors linked to diabetic complications. To determine the changes in lipid and lipoprotein profile in patients with insulin dependent diabetes mellitus [IDDM]. Sixty-four IDDM patients [28 males and 36 females] and 120 control subjects [35 males and 85 females] were included in this prospective study. In patients and controls, serum concentrations of glucose [fasting blood sugar [FBS]], total cholesterol [TC], high density lipoprotein-cholesterol [HDL-C], low density lipoprotein-cholesterol [LDL-C], triglyceride [TG], and very low density lipoprotein- cholesterol [VLDL-C] were measured. In patients with IDDM,TC [p 0.01] LDL-C TG, VLDL-C serum levels [P< 0.05] and LDL-C / HDL-C ratio [P< 0.001] were significantly higher, and serum HDL-C level [P < 0.001] was significantly lower in comparison to control subjects. In males, serum HDL-C concentration [P< 0.05] was significantly lower in IDDM patients compared to controls, whereas, no significant differences seen in TC,LDL-C, TG,VLDL-C and LDL-C /HDL-C ratio among patients and control subjects [P> 0.05]. In females, IDDM patients have significantly higher serum levels of TC,TG [P< 0.05], VLDL-C [P< 0.05], LDL-C [p 0.01] and LDL-C/ HDL-C ratio [P< 0.001], and significantly lower serum HDL-C level [P< 0.001] compared to controls. IDDM patients are at a greater risk of dyslipidemia than normal individuals, and females are more prone than males, and hence, would be more susceptible to atherosclerosis and coronary artery disease [CAD]